Over the past decade, much has changed in computational research. With the end of the hype era of “big data” and soon to be of “AI”, centers like the Texas Advanced Computing Center (TACC) are working in both fields new to computational research, like humanities and biology, and those with a firm background in traditional model driven computational research like Physics and Astronomy. In this talk, I will briefly discuss advancements in the capacities and capabilities of modern super computing and how new technologies and techniques are changing all aspects of computational research. How applications in both data driven research and those supported by more real-time cloud-like services are changing what is possible in observational research, and how similar techniques are improving how traditional model driven computations are carried out. Finally I will go into details of several projects, ranging from Muliti-messenger astronomy and computational biology to less standard areas like traffic safety and natural hazard engineering share many computational requirements and need support from centers like TACC.